Molecular Pharmacology
The course will study the molecular basis of drug action, protein structure-activity relationships, receptor-ligand interactions, signal transduction, different types of receptors from molecular point of view and their signalling mechanisms, quantitative aspects of ligand binding, receptor antagonism, functional selectivity, biologicals, mechanisms of drug resistance in cancer, consequences of genetic and epigenetic alteration in cancer, role of miRNA and its applications.
Teaching methods
• Lectures
• E-Lab
- Course CodeOPPM 305
- ModuleModule 3
- Credit Hours6ECTS/3EG/3LB
- Define pharmacological terms and concepts and outline the modes of action of drug at the cellular level.
- Differentiate between the primary characteristics of the principal superfamilies of drug targets (ligand-gated ion channels, growth factor receptors, steroid receptors and their signalling mechanisms)
- Summarize the development of biological and biotechnological drugs, mechanisms of drug resistance in cancer and consequences of genetic and epigenetic alteration in cancer.
- Detect the role of miRNA and possibilities of diagnostics and therapeutic applications
- Analyze methods of radio-ligand binding techniques and their application in the study of the receptor molecular pharmacology.
- Predict potential new sites of drug action in the relevant cell signaling pathways.
- Develop contemporary application of scientific advances in the discipline of molecular pharmacology.