Clinical Drug Safety
This course covers the principles of individualization of drug therapy in different clinical setting, drug use in renal patients, special populations and during idiosyncratic reactions. Pharmacogenetics, drug-drug interactions and adverse drug reactions are covered in this context.
Teaching methods
• Lectures
• Practical sessions
• E-Lab
- Course CodeOPPM 202
- ModuleModule 2
- Credit Hours8ECTS/3EG/3LB
- Outline clinically relevant diversity in age, sex and genetic related variations that affects drug response.
- Recognize basic principles of dose adjustment and factors contributing to individual variability in different clinical situations
- Describe different types of drug-drug interactions and their impacts on patient safety issues
- Describe the rationale for proper drug choice in kidney failure
- Define pharmacovigilance and the importance of drug information centers
- Underline Pharmacogenetic issues related to drugs according to CPIC recommendations
- Analyze data and problems related to genetic variability and its impact on drug dosing and side effects.
- Explain types of adverse drug reactions and hypersensitivity reactions, their association with poor medication compliance and the impact of pharmacogenetic testing
- Analyze inter-individual differences or changes in pharmacokinetics parameters due to genetics, sex and cardiac, renal, or hepatic function
- Categorize the seriousness, expectedness, and causality of adverse events
- Apply pharmacovigilance concepts and procedures in the drug information centers
- Evaluate research articles in adverse drug reactions and interactions issues
- Discuss the history, principles, and regulatory framework for clinical drug safety
- Evaluate risk factors and possible dose adjustment of drugs-induced pro-arrhythmias
- Effectively communicate their understanding of research through presentation
- Develop professional documents pertinent to organizational needs (e.g., monographs, policy documents).
- Apply the information technology to remain updated with the recent advances in professional practices