Introduction to Pharmacogenomics
This course will introduce to learners the concepts of pharmacogenetics and pharmacogenomics, and provide a brief history of pharmacogenomics and personalized medicine. It will cover examples of pharmacogenomic polymorphisms relevant to drug metabolism, drug transport, drug targets and immune complexes, and differentiate between somatic and germline variants in diseases such as cancer. Methods and ethical issues in pharmacogenomics will be discussed in addition to the pharmacogenomics of special diseases such as cystic fibrosis. The course will help learners understand pharmacogenomics data to potentially choose the appropriate drug or dose for a certain patient based on pharmacogenomic testing.
Teaching methods
• Lectures
• E-Lab
- Course CodeOPPM 201
- ModuleModule 2
- Credit Hours8ECTS/3EG/3LB
- Recognize how the principles of human genetics are employed to optimize drug therapy and patient care.
- Identify the genetic basis of variability in drug response and how it contributes to drug efficacy and toxicity, adverse drug reactions, and drug-drug interaction.
- Explain how gene variants can affect the pharmacokinetics and/or pharmacodynamics of drugs.
- Analyse pharmacogenomic test results from different genotyping methods.
- Explain pharmacogenomic concepts to a particular drug therapy to solve relevant problems in healthcare.
- Illustrate legal and ethical issues of pharmacogenomic testing.
- Outline social and economic issues of implementation of pharmacogenetic in health care
- Identify the key components and steps required for successful implementation of pharmacogenomics in clinical practice.
- Recognize emerging advances in the pharmacogenomics field.